Scientists report that a new compound, P7C3-A20, fully reversed cognitive decline in mouse models of late-stage Alzheimer’s disease. 

The research focused on restoring levels of NAD⁺, a molecule essential for cellular energy and brain health that declines with age and is severely reduced in Alzheimer’s patients. Mice genetically engineered to develop amyloid plaques or tau tangles regained normal cognition and brain function after treatment, even when the disease was already advanced. The compound appeared to stabilize brain metabolism, reduce inflammation, and repair damaged neural circuits across both models. 

Researchers say the results suggest Alzheimer’s-related brain damage may not be permanently irreversible under the right biological conditions. While the findings are limited to animals, they add to growing evidence that targeting brain energy balance could lead to more effective future therapies for humans.